Visfatin, glucose metabolism and vascular disease: a review of evidence

Table 1 Association between several medical conditions and visfatin

Medical Condition	Visfatin
Atherosclerosis	Increased serum levels [10, 31] Increased expression in instable plaques [31]
Endothelial dysfunction	Increased serum levels [18]
Cardioprotection	Reduces infarct area [36]
Metabolic Syndrome	Controversial, Increased serum levels [34]
Adiponectin	Controversial [18, 27]
Hepatic Fat Disease	Diminished serum levels in steatohepatitis [16] Increased serum levels with progressive portal inflammation [17]
Tumoral replication	Visfatin antagonist being tested [19]
Acute lung injury	Increased serum levels [15]
Renal insufficiency	Increased serum levels [18]
Beta cell function impairment	Increased serum levels [10, 22, 23, 28, 29]
Insulin resistance	No correlation [20, 22, 23]
Insulin-mimetic effect	Controversial, no effect [5, 10, 15–20, 22–24, 27–29]
Diabetes	Controversial [18, 23, 27, 28]
Obesity	Increased serum levels [20, 22]
Visceral Fat	Controversial, no correlation [5, 15–20, 27]
Vascular smooth muscle	Promotes inflammation [32]

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