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Table 1 Maternal reproductive outcomes of control, severe diabetic and mild diabetic rats

From: Animal models for clinical and gestational diabetes: maternal and fetal outcomes

Variables Control Severe diabetes Mild diabetes
Number of rats used 16 50 30
Number of rats that achieved inclusion criteria 16 (100%) 18 (36%) 6 (20%)
Implantation number 159 199 70
   Mean ± SEM 11.67 ± 0.33 11.71 ± 0.39 11.67 ± 0.56
Live fetus number 153 115 66
   Mean ± SEM 11.50 ± 0.22 6.76 ± 1.15a, b 11.00 ± 0.37
Pre-implantation loss (%) 4.85% 8,44% 1,52%
Post-implantation loss (%) 1.28% 42,27%c, d 5,24%
  1. Rats were injected with citrate buffer solution (control), streptozotocin as adults (severe diabetes) and streptozotocin during the neonatal period (mild diabetes). Values are presented as mean ± standard deviation and proportions (%). aP < 0.05 - statistically significant difference compared to control group (Student Newman Keuls); bP < 0.05 - statistically significant difference compared to mild diabetes group (Student Newman Keuls); cP < 0.05 - statistically significant difference compared to control group (Mann Whitney); dP < 0.05 - statistically significant difference compared to mild diabetes group (Mann Whitney). SEM, standard error of the mean.