Table 2 Concentrations of inflammatory markers by polymorphisms in the TCF7L2 genea
From: TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
Variable | rs12255372 (G>T) | rs7903146 (C>T) | ||||
|---|---|---|---|---|---|---|
Before fenofibrate | GG | GT | TT | CC | CT | TT |
n | 512 | 390 | 115 | 514 | 398 | 113 |
CRP, mg/dL | 0.23 (0.37) | 0.25 (0.59) | 0.33 (0.82) | 0.23 (0.36) | 0.25 (0.57) | 0.31 (0.79) |
IL-2 sR alpha, pg/mL | 1014 (375) | 1035 (353) | 991 (332) | 1021 (384) | 1029 (350) | 990 (324) |
IL-6, pg/mL | 2.04 (3.90) | 1.88 (2.31) | 1.88 (1.98) | 2.10 (4.16) | 1.74 (1.28) | 2.00 (2.39) |
TNF-alpha, pg/mL | 3.25 (2.48) | 3.73 (8.07) | 3.35 (2.79) | 3.28 (2.48) | 3.68 (7.99) | 3.36 (2.72) |
MCP-1, pg/mL | 208 (58) | 212 (78) | 205 (51) | 209 (58) | 210 (78) | 207 (49) |
After fenofibrate | ||||||
n | 373 | 300 | 89 | 373 | 307 | 96 |
hsCRP, mg/dL | 0.22 (0.35) | 0.29 (0.53) | 0.30 (0.61) | 0.22 (0.37) | 0.30 (0.54) | 0.25 (0.50) |
IL-2 sR alpha, pg/mL | 1161 (539) | 1186 (580) | 1086 (354) | 1169 (541) | 1186 (573) | 1063 (336) |
IL-6, pg/mL | 2.22 (4.23) | 2.24 (2.68) | 1.86 (2.08) | 2.24 (4.34) | 2.12 (2.21) | 1.99 (2.19) |
TNF-alpha, pg/mL | 3.52 (2.36) | 3.99 (5.99) | 3.64 (2.53) | 3.55 (2.36) | 3.96 (5.93) | 3.58 (2.46) |
MCP-1, pg/mL | 179 (94) | 186 (102) | 197 (80) | 179 (93) | 187 (103) | 197 (77) |