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Table 6 Mean percent blood glucose reduction in normal rabbits (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Nevirapine Nevirapine + Gliclazide*(Single dose treatment) Nevirapine + Gliclazide*(Multiple dose treatment)
1 19.44 ± 2.25 02.08 ± 2.38 21.09 ± 2.93 20.39 ± 2.00
2 26.73 ± 2.57 03.57 ± 2.48 25.38 ± 2.40 26.56 ± 0.90
3 36.18 ± 1.08 05.72 ± 2.23 34.38 ± 0.69 35.18 ± 1.39
4 28.90 ± 3.23 04.59 ± 2.66 26.48 ± 1.47 27.61 ± 1.83
6 24.62 ± 2.00 02.53 ± 1.89 23.21 ± 2.51 25.49 ± 1.05
8 19.13 ± 2.46 02.50 ± 1.42 18.59 ± 1.80 19.63 ± 2.79
12 14.46 ± 1.76 02.82 ± 2.51 12.87 ± 0.86 12.49 ± 1.91
16 08.23 ± 1.85 01.00 ± 2.29 06.36 ± 2.31 07.14 ± 0.99
20 04.99 ± 1.49 01.04 ± 1.54 03.92 ± 1.52 05.33 ± 1.18
24 02.14 ± 1.09 00.63 ± 1.94 01.37 ± 1.43 03.87 ± 1.91
  1. *Statistically no significance compared to gliclazide control