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Table 5 Mean percent blood glucose reduction in diabetic rats (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Nevirapine Nevirapine + Gliclazide*(Single dose treatment) Nevirapine + Gliclazide*(Multiple dose treatment)
1 33.45 ± 1.76 02.08 ± 0.38 32.42 ± 1.47 33.23 ± 1.63
2 42.50 ± 1.40 04.34 ± 1.40 41.68 ± 1.27 42.28 ± 1.32
3 31.87 ± 1.68 04.42 ± 1.62 30.69 ± 1.61 31.66 ± 1.66
4 25.88 ± 1.42 06.11 ± 1.61 25.43 ± 1.47 25.82 ± 1.34
6 36.89 ± 1.30 06.28 ± 1.53 36.25 ± 1.48 36.78 ± 1.38
8 44.46 ± 1.46 03.08 ± 0.54 43.25 ± 1.35 44.37 ± 1.33
10 28.72 ± 1.76 01.67 ± 0.67 27.93 ± 1.55 28.92 ± 1.68
12 24.39 ± 1.81 01.64 ± 0.71 23.81 ± 1.80 24.98 ± 1.83
  1. *Statistically no significance compared to gliclazide control