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Table 4 Mean percent blood glucose reduction in normal rats (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Nevirapine Nevirapine + Gliclazide*(Single dose treatment) Nevirapine + Gliclazide*(Multiple dose treatment)
1 30.88 ± 1.12 -01.44 ± 0.46 30.43 ± 1.09 30.83 ± 0.94
2 40.72 ± 0.56 02.88 ± 0.45 38.35 ± 0.72 40.49 ± 0.84
3 28.34 ± 0.82 03.96 ± 0.64 26.84 ± 0.79 28.30 ± 0.68
4 23.97 ± 0.79 04.68 ± 0.65 22.90 ± 0.99 23.63 ± 1.13
6 30.90 ± 0.46 02.51 ± 0.66 30.42 ± 1.00 31.53 ± 0.67
8 37.46 ± 1.18 01.43 ± 0.71 35.14 ± 1.23 37.62 ± 1.44
10 24.73 ± 0.69 01.05 ± 1.66 23.61 ± 1.01 25.81 ± 0.76
12 10.52 ± 1.14 00.34 ± 1.40 10.33 ± 1.30 11.80 ± 1.16
  1. *Statistically no significance compared to gliclazide control