Time (h) | Gliclazide | Efavirenz | Efavirenz + Gliclazide (Single dose treatment) | Efavirenz + Gliclazide (Multiple dose treatment) |
---|---|---|---|---|
1 | 18.30 ± 1.88 | -04.36 ± 1.49 | 09.25 ± 1.37*** | 11.54 ± 1.24*** |
2 | 24.50 ± 1.24 | -06.16 ± 1.93 | 14.96 ± 1.12*** | 16.61 ± 1.21*** |
3 | 34.25 ± 0.99 | -03.63 ± 1.24 | 24.97 ± 0.87*** | 27.14 ± 0.67*** |
4 | 25.92 ± 1.30 | -01.48 ± 1.22 | 14.61 ± 1.22*** | 16.97 ± 1.40*** |
6 | 24.50 ± 0.96 | -00.04 ± 0.98 | 12.44 ± 1.59*** | 14.05 ± 1.53*** |
8 | 18.96 ± 2.85 | 02.09 ± 1.94 | 10.69 ± 0.70*** | 12.28 ± 0.80** |
12 | 10.39 ± 1.32 | 04.22 ± 2.31 | 08.89 ± 1.23 | 10.78 ± 1.86 |
16 | 05.71 ± 1.13 | 06.03 ± 1.87 | 04.59 ± 1.35 | 06.51 ± 0.54 |
20 | 04.24 ± 1.54 | 05.31 ± 2.28 | 03.17 ± 1.29 | 03.87 ± 2.26 |
24 | 02.08 ± 1.47 | 04.60 ± 1.78 | 01.42 ± 0.45 | 02.85 ± 0.90 |