Skip to main content

Advertisement

Table 3 Mean percent blood glucose reduction in normal rabbits (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Efavirenz Efavirenz + Gliclazide (Single dose treatment) Efavirenz + Gliclazide (Multiple dose treatment)
1 18.30 ± 1.88 -04.36 ± 1.49 09.25 ± 1.37*** 11.54 ± 1.24***
2 24.50 ± 1.24 -06.16 ± 1.93 14.96 ± 1.12*** 16.61 ± 1.21***
3 34.25 ± 0.99 -03.63 ± 1.24 24.97 ± 0.87*** 27.14 ± 0.67***
4 25.92 ± 1.30 -01.48 ± 1.22 14.61 ± 1.22*** 16.97 ± 1.40***
6 24.50 ± 0.96 -00.04 ± 0.98 12.44 ± 1.59*** 14.05 ± 1.53***
8 18.96 ± 2.85 02.09 ± 1.94 10.69 ± 0.70*** 12.28 ± 0.80**
12 10.39 ± 1.32 04.22 ± 2.31 08.89 ± 1.23 10.78 ± 1.86
16 05.71 ± 1.13 06.03 ± 1.87 04.59 ± 1.35 06.51 ± 0.54
20 04.24 ± 1.54 05.31 ± 2.28 03.17 ± 1.29 03.87 ± 2.26
24 02.08 ± 1.47 04.60 ± 1.78 01.42 ± 0.45 02.85 ± 0.90
  1. ***Significant at P < 0.001 compared to gliclazide control
  2. **Significant at P < 0.01 compared to gliclazide control