Time (h) | Gliclazide | Efavirenz | Efavirenz + Gliclazide (Single dose treatment) | Efavirenz + Gliclazide (Multiple dose treatment) |
---|---|---|---|---|
1 | 32.92 ± 1.95 | -04.55 ± 2.55 | 24.83 ± 1.98** | 28.26 ± 1.62 |
2 | 42.05 ± 1.73 | -05.08 ± 2.46 | 30.02 ± 1.59*** | 36.39 ± 1.89* |
3 | 31.21 ± 1.74 | -03.21 ± 2.41 | 20.70 ± 1.31*** | 25.45 ± 1.93* |
4 | 25.13 ± 1.77 | -02.40 ± 2.24 | 16.78 ± 2.21*** | 20.78 ± 1.36* |
6 | 36.14 ± 1.56 | 03.99 ± 1.97 | 22.15 ± 1.34*** | 30.12 ± 1.47* |
8 | 44.05 ± 1.55 | 04.45 ± 2.26 | 32.01 ± 1.39*** | 38.27 ± 1.42* |
10 | 28.56 ± 1.87 | 05.39 ± 1.72 | 16.25 ± 2.25*** | 20.89 ± 1.49** |
12 | 24.66 ± 2.32 | 04.28 ± 1.53 | 08.49 ± 2.32*** | 11.31 ± 2.17*** |