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Table 2 Mean percent blood glucose reduction in diabetic rats (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Efavirenz Efavirenz + Gliclazide (Single dose treatment) Efavirenz + Gliclazide (Multiple dose treatment)
1 32.92 ± 1.95 -04.55 ± 2.55 24.83 ± 1.98** 28.26 ± 1.62
2 42.05 ± 1.73 -05.08 ± 2.46 30.02 ± 1.59*** 36.39 ± 1.89*
3 31.21 ± 1.74 -03.21 ± 2.41 20.70 ± 1.31*** 25.45 ± 1.93*
4 25.13 ± 1.77 -02.40 ± 2.24 16.78 ± 2.21*** 20.78 ± 1.36*
6 36.14 ± 1.56 03.99 ± 1.97 22.15 ± 1.34*** 30.12 ± 1.47*
8 44.05 ± 1.55 04.45 ± 2.26 32.01 ± 1.39*** 38.27 ± 1.42*
10 28.56 ± 1.87 05.39 ± 1.72 16.25 ± 2.25*** 20.89 ± 1.49**
12 24.66 ± 2.32 04.28 ± 1.53 08.49 ± 2.32*** 11.31 ± 2.17***
  1. ***Significant at P < 0.001 compared to gliclazide control
  2. **Significant at P < 0.01 compared to gliclazide control
  3. *Significant at P < 0.05 compared to gliclazide control