Table 1 Mean percent blood glucose reduction in normal rats (N = 6)
Time (h) | Gliclazide | Efavirenz | Efavirenz + Gliclazide (Single dose treatment) | Efavirenz + Gliclazide (Multiple dose treatment) |
|---|---|---|---|---|
1 | 31.46 ± 1.39 | -06.66 ± 2.95 | 24.40 ± 1.20*** | 26.57 ± 1.09* |
2 | 41.64 ± 0.80 | -04.44 ± 1.44 | 33.77 ± 0.87** | 36.26 ± 1.53* |
3 | 28.21 ± 0.95 | -02.94 ± 0.96 | 21.19 ± 1.15*** | 22.26 ± 0.99** |
4 | 24.21 ± 1.13 | -00.06 ± 1.80 | 16.16 ± 0.79*** | 18.68 ± 0.96*** |
6 | 31.47 ± 1.46 | 02.14 ± 1.49 | 23.34 ± 1.09*** | 28.71 ± 1.85 |
8 | 38.70 ± 1.43 | 04.29 ± 1.09 | 28.36 ± 1.70*** | 31.21 ± 2.03** |
10 | 26.08 ± 1.02 | 06.86 ± 1.78 | 19.00 ± 1.44*** | 20.45 ± 1.11** |
12 | 12.27 ± 1.55 | 06.13 ± 1.59 | 08.27 ± 0.64 | 08.98 ± 1.02 |