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Table 1 Mean percent blood glucose reduction in normal rats (N = 6)

From: Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models

Time (h) Gliclazide Efavirenz Efavirenz + Gliclazide (Single dose treatment) Efavirenz + Gliclazide (Multiple dose treatment)
1 31.46 ± 1.39 -06.66 ± 2.95 24.40 ± 1.20*** 26.57 ± 1.09*
2 41.64 ± 0.80 -04.44 ± 1.44 33.77 ± 0.87** 36.26 ± 1.53*
3 28.21 ± 0.95 -02.94 ± 0.96 21.19 ± 1.15*** 22.26 ± 0.99**
4 24.21 ± 1.13 -00.06 ± 1.80 16.16 ± 0.79*** 18.68 ± 0.96***
6 31.47 ± 1.46 02.14 ± 1.49 23.34 ± 1.09*** 28.71 ± 1.85
8 38.70 ± 1.43 04.29 ± 1.09 28.36 ± 1.70*** 31.21 ± 2.03**
10 26.08 ± 1.02 06.86 ± 1.78 19.00 ± 1.44*** 20.45 ± 1.11**
12 12.27 ± 1.55 06.13 ± 1.59 08.27 ± 0.64 08.98 ± 1.02
  1. ***Significant at P < 0.001 compared to gliclazide control
  2. **Significant at P < 0.01 compared to gliclazide control
  3. *Significant at P < 0.05 compared to gliclazide control